The San Francisco 49ers lead the way in our NFL Week 4 DEF Rankings as they are set to face the Arizona Cardinals at home.

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Here are the Positional Rankings from FantasyTeamAdvisors.com for your NFL Week 4 DEF Rankings
NFL Week 4 DEF Rankings
NFL Week 4 DEF Rankings
RK
PLAYER NAME
TEAM
OPP
1
Denver Broncos
DEN
vs. CIN
2
Houston Texans
HOU
vs. TEN
3
Buffalo Bills
BUF
vs. NO
4
Detroit Lions
DET
vs. CLE
5
Los Angeles Chargers
LAC
at NYG
6
Minnesota Vikings
MIN
at PIT
7
Green Bay Packers
GB
at DAL
8
Philadelphia Eagles
PHI
at TB
9
New England Patriots
NE
vs. CAR
10
Pittsburgh Steelers
PIT
vs. MIN
11
Seattle Seahawks
SEA
at ARI
12
San Francisco 49ers
SF
vs. JAC
13
Arizona Cardinals
ARI
vs. SEA
14
Tennessee Titans
TEN
at HOU
15
New York Jets
NYJ
at MIA
16
Washington Commanders
WAS
at ATL
17
Chicago Bears
CHI
at LV
18
Baltimore Ravens
BAL
at KC
19
Los Angeles Rams
LAR
vs. IND
20
Miami Dolphins
MIA
vs. NYJ
21
Atlanta Falcons
ATL
vs. WAS
22
Jacksonville Jaguars
JAC
at SF
23
Carolina Panthers
CAR
at NE
24
Cleveland Browns
CLE
at DET
25
Indianapolis Colts
IND
at LAR
26
New York Giants
NYG
vs. LAC
27
Kansas City Chiefs
KC
vs. BAL
28
Tampa Bay Buccaneers
TB
vs. PHI
29
Las Vegas Raiders
LV
vs. CHI
30
Cincinnati Bengals
CIN
at DEN
31
Dallas Cowboys
DAL
vs. GB
32
New Orleans Saints
NO
at BUF
| RK | PLAYER NAME | TEAM | OPP |
| 1 | Denver Broncos | DEN | vs. CIN |
| 2 | Houston Texans | HOU | vs. TEN |
| 3 | Buffalo Bills | BUF | vs. NO |
| 4 | Detroit Lions | DET | vs. CLE |
| 5 | Los Angeles Chargers | LAC | at NYG |
| 6 | Minnesota Vikings | MIN | at PIT |
| 7 | Green Bay Packers | GB | at DAL |
| 8 | Philadelphia Eagles | PHI | at TB |
| 9 | New England Patriots | NE | vs. CAR |
| 10 | Pittsburgh Steelers | PIT | vs. MIN |
| 11 | Seattle Seahawks | SEA | at ARI |
| 12 | San Francisco 49ers | SF | vs. JAC |
| 13 | Arizona Cardinals | ARI | vs. SEA |
| 14 | Tennessee Titans | TEN | at HOU |
| 15 | New York Jets | NYJ | at MIA |
| 16 | Washington Commanders | WAS | at ATL |
| 17 | Chicago Bears | CHI | at LV |
| 18 | Baltimore Ravens | BAL | at KC |
| 19 | Los Angeles Rams | LAR | vs. IND |
| 20 | Miami Dolphins | MIA | vs. NYJ |
| 21 | Atlanta Falcons | ATL | vs. WAS |
| 22 | Jacksonville Jaguars | JAC | at SF |
| 23 | Carolina Panthers | CAR | at NE |
| 24 | Cleveland Browns | CLE | at DET |
| 25 | Indianapolis Colts | IND | at LAR |
| 26 | New York Giants | NYG | vs. LAC |
| 27 | Kansas City Chiefs | KC | vs. BAL |
| 28 | Tampa Bay Buccaneers | TB | vs. PHI |
| 29 | Las Vegas Raiders | LV | vs. CHI |
| 30 | Cincinnati Bengals | CIN | at DEN |
| 31 | Dallas Cowboys | DAL | vs. GB |
| 32 | New Orleans Saints | NO | at BUF |
Our Other NFL Week 4 Rankings:
QB Rankings
RB Rankings
WR Rankings
TE Rankings
NFL DFS LINEUP
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REMEMBER: These are lineups we use but feel free to pick and choose plays and make your own lineups. Don’t ALWAYS follow these as they don’t hit 100% of the time. We do use these but sometimes late scratches happen and it’s too late to update the lineup. Good luck and bring home the bacon.