NFL DFS WEEK 10 Top Defense Pick

WEEK 10 DFS Defense Picks: Top Plays for FanDuel & DraftKings Main Slate

It’s Week 10, and the NFL season is in full-throttle mode. As the leaves change, the race for the playoffs is heating up, and the defenses are ready to lock down offenses. You want a DFS lineup that doesn’t just play it safe but puts you in a position to win big. This week’s slate features some intriguing matchups and a few under-the-radar defenses that could be poised for a breakout.

This isn’t just a list of names—it’s the backbone of a lineup that could cash in, leaving your friends wondering how you saw the potential. We’re talking about the defenses that aren’t just about keeping scores low but about racking up sacks, picks, and points. Let’s break down which teams have the odds in their favor, and why these defenses might just make you a winner in Week 10.

NFL DFS Week 10 Defense Picks

Philadelphia Eagles: Grounding the Cowboys

• FanDuel: $5,100
• DraftKings: $3,500

With one of the most aggressive defensive fronts, the Eagles are in a prime spot against Dallas’ backup QB Cooper Rush. Expect sacks and turnovers as Philadelphia’s elite pass rush disrupts any offensive flow. The Eagles come with a premium price, but their upside and defensive consistency make them worth every dollar.

NFL DFS Week 10 Defense Picks

San Francisco 49ers: Blocking Out the Buccaneers

• FanDuel: $4,400
• DraftKings: $3,300

San Francisco’s defense thrives under pressure, and Baker Mayfield’s tendency to make mistakes under duress makes this a favorable matchup. With the 49ers’ aggressive style and a high chance of sacks and turnovers, they’re a top-tier pick that could pay off big in DFS.

NFL DFS Week 10 Defense Picks

New England Patriots: Rookie Trap vs. the Bears

FanDuel: $3,600

DraftKings: $2,500

Rookie QB Caleb Williams is up against a Patriots defense with a reputation for exposing inexperienced QBs, especially under their new coaching regime. The New England defense has shown an ability to generate sacks and force turnovers, making them a solid value pick with high upside in DFS. At this mid-tier price, they offer strong potential for a rewarding return on your investment.

NFL DFS Week 10 Defense PicksAtlanta

Atlanta Falcons: Pouncing on the Saints

• FanDuel: $3,600
• DraftKings: $3,000

The Falcons defense, often under the radar, has an opportunistic matchup against Derek Carr and the Saints. Carr’s tendency to throw risky passes makes Atlanta a strong, affordable option, offering decent upside for DFS players looking to save salary.

Final Thoughts: Unlocking Week 10 DFS Defense Value

So there you have it—defenses that are ready to make an impact this week, with the potential to turn the tide in your DFS lineup. Whether you’re targeting elite pass rushes, capitalizing on rookie QBs, or seizing on an offense prone to mistakes, these picks have the upside to deliver big returns. Week 10 promises fireworks, and with these defenses in your corner, you’re setting yourself up to hit the jackpot. The road to victory is paved with smart, strategic picks—and these defenses are your ticket to the top.

NFL DFS LINEUP

You can find the new and improved lineups here: NFL LINEUPS We are very proud to bring you tons of great info and lineups each week!

REMEMBER: These are lineups we use but feel free to pick and choose plays and make your own lineups. Don’t ALWAYS follow these as they don’t hit 100% of the time. We do use these but sometimes late scratches happen and it’s too late to update the lineup. Good luck and bring home the bacon.