MLB DFS TOP STACKS 5/22/2025 and EXPERT ANALYSIS FOR FANDUEL and DRAFTKINGS MLB DFS MAIN SLATE (May,22)

MLB DFS Picks Today 5/22/25 Advice for Fanduel and DraftKings Advice can be used for the 16 games today. FantasyTeamAdvisors is very excited to be able to provide you with some MLB content once again. Let’s dig in!

Make sure to also check out all the Vegas Odds for today’s slate. You can also read more DFS advice and lineup picks for sites like FanDuel, and other sports too. If you have any questions or comments, feel free to hit me up on Twitter @advisors_team

MLB DFS Picks Today 5/22/25

When playing MLB DFS (Daily Fantasy Sports) on FanDuel and DraftKings, there are several strategies you can employ to increase your chances of success. Here are a few key strategies to consider:

Research and Study: Familiarize yourself with the players, teams, and matchups. Analyze player statistics, recent performance, and factors like weather conditions, ballpark tendencies, and pitching matchups. Stay updated on injury news and lineup changes to make informed decisions.
Focus on Starting Pitching: Starting pitchers have a significant impact on DFS performance. Target pitchers with high strikeout potential, favorable matchups, and a track record of consistent performance. Look for pitchers who can go deep into games and limit runs scored by the opposing team.
Consider Ballpark Factors: Ballpark dimensions and factors can greatly influence a player’s performance. Some ballparks are known for being hitter-friendly, while others favor pitchers. Take these factors into account when selecting your lineup, particularly when choosing power hitters or pitchers susceptible to giving up home runs.
Look for Value Plays: Identify undervalued players who have the potential to outperform their price tag. These can be players who are in favorable matchups, hitting higher in the batting order, or experiencing recent success. Finding value plays allows you to roster top-tier players while staying within the salary cap.
Diversify Lineups: Consider creating multiple lineups with different player combinations. This strategy, known as lineup diversification, helps reduce risk and increases the chances of hitting on the right combination of players. It’s important to strike a balance between diversification and maintaining exposure to top performers.
Pay Attention to Vegas Lines: Keep an eye on the Vegas lines and over/under totals for games. High-scoring games can provide more opportunities for hitters, while low-scoring games may favor pitchers. Target games with high run totals or favorable odds for potential offensive explosions.
Monitor Late Lineup Changes: Stay vigilant and adjust your lineup accordingly if there are any late lineup changes or player scratches. This ensures you have active players in your lineup and maximizes your potential points.

Remember, DFS success requires a combination of skill, research, and a bit of luck. It’s essential to continually evaluate your strategies, learn from your mistakes, and adapt to changing circumstances to improve your MLB DFS performance on FanDuel.

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DFS MLB Stacks for Thursday May 22: Swinging for the Fences Like It’s the Summer of “Scandal”

It’s Thursday night. You’ve just seen the trailer for Jurassic World Rebirth, remembered you never finished the last episode of The Last of Us, and Taylor Swift just dropped another remix that’s already trending on TikTok. But while the world scrolls, the sharpest minds in DFS are locking in lineups for FanDuel and DraftKings’ 6:40 PM main slate. And tonight, we’re not here to play small ball.

We’re here to stack the lumber. Whether you’re spraying entries like a Wall Street shark or locking in that one perfect bullet, these are three DFS MLB stacks built to go in!

🔥 OPTIMAL STACK: Atlanta Braves @ Nationals (6:40 PM ET) vs. (Trevor Williams)

You want optimal? You want firepower? You want Atlanta.

Trevor Williams is the human version of a hanging slider. The Braves have faced him 146 times and have racked up a .259 AVG and a .296 wOBA, but those are floor numbers. Williams is a contact-heavy arm with a measly 15.8% K rate and a .384 xSLG. Translation? The ball is going to be in play—and hard.

Stack Targets:
- Matt Olson – Smashes righties like it’s his job (because it is).
- Ozzie Albies – A switch-hitting middle infielder with power? Yes, please.
- Austin Riley – The guy who reminds us all that third base isn’t just a power position—it’s a money spot.

⚖️ Moderate Stack: Cleveland Guardians @ Detroit Tigers (6:40 PM ET) vs.

(Tanner Bibee)

Why this stack?
Tanner Bibee might have a better K rate than his 4.06 ERA suggests, but Detroit’s expected lineup has enough lefty pop to make him work. Bibee has allowed a .307 AVG and .368 wOBA to this current Tigers group over 116 plate appearances. Statcast isn’t smiling here: a .316 xBA and .543 xSLG are asking to be punished.

Stack Targets:

Riley Greene – A .400+ OBP against righties and enough speed to steal a bag when no one’s looking.
Kerry Carpenter – The underrated power bat with a .530+ SLG vs RHP this season.
Colt Keith – He’s finally heating up, and he’s got the swing to take advantage of Bibee’s flat slider.
Zach McKinstry – The utility guy who gives you positional flexibility and sneaky stack value.

🕵️ Sneaky Stack: Houston Astros @ Seattle Mariners (8:10 PM ET) vs.

(George Kirby)

Why this stack?

People are sleeping on this game like it’s an 11:00 PM West Coast slate, but George Kirby, despite his minuscule 1.1% walk rate, has allowed an xSLG over .340 to this Astros roster. Houston’s expected lineup is packed with power and contact hitters—exactly the type of bats that can pressure George Kirby into mistakes.

Stack Targets:

Jose Altuve – The vet isn’t slowing down and has .300+ AVG vs. RHP.
Christian Walker – The offseason pickup continues to slug in the cleanup role.
Yainer Diaz – Quietly raking with a sub-15% K rate and real pop.
Isaac Paredes – Brings OBP and power to the middle third.

🎯 Conclusion:Three Data-Driven Stacks to Maximize Your DFS ROI”

This slate isn’t about playing it safe—it’s about capitalizing on matchups that tilt the board. The Braves are the juggernaut play: elite power, deep order, and a plus matchup against a hittable arm. The Tigers aren’t a fluke—they’re in first place because they grind out at-bats and punish mistakes. Against Bibee, whose surface numbers mask his struggles against lefty-heavy lineups, Detroit’s value is real. And the Astros? Don’t sleep. They’re not old news—they’re just waiting to remind the slate who runs the AL West.

Pick your spots, plant your flags, and stack like you mean it—because tonight, the edge belongs to the bold.